When his wife is abducted by a group of blood-thirsty Vampires, John Croix is left to die in a forgotten region of the desert. It is here where an unspeakable evil exists. Now, by no choice of his own, Croix will come face-to-face with the most terrifying creatures of the night. Still a man, but possessing all the strength and power of a werewolf when the moon is out, Croix becomes a reluctant hero for mankind when he learns that his wife may still be alive. Croix sets out on a mission to rescue his wife - venturing deeper and deeper into the Vampire's lair- in his quest to save her before she is lost to the world of the undead forever.

In 1889, a reclusive gun-for-hire, Cole Brandt, travels the barren Arizona desert bringing wanted fugitives to justice, dead or alive. He drifts from town to town, hunting down and seeking revenge on the men who killed his wife and child five years prior. When his travels take him to the lawless town of Dead River, he signs on to protect The Majestic Saloon, owned by Thomas Morgan and his wife, Sarah. Brandt soon meets a beautiful, innocent prostitute, Cassey May, who works at The Raven, the local brothel and hotel. Travis McCain, the owner of The Raven, is an outlaw who has taken control of Dead River, leaving the residents to live in fear of McCain and his rouge group of men. McCain soon learns about the relationship between Brandt and Cassey May, and threatens Cassey May with her life. Cassey May defies McCain, escaping The Raven, seeking protection with Sarah and Brandt at The Majestic Saloon...